5 August 2015 Professor Mark Middleton appointed to Physiomics SAB
28 April 2015 Workshop on Applications of Physiomics’ Virtual Tumour to Immunotherapy and Translational Science- June 2, 2015, Hersonissos (Greece)
22 April 2015 Physiomics to present new developments of the Virtual Tumour platform in immunotherapy at AACR Annual Meeting 2015
3 March 2015 First contract for a clinical version of our Virtual Tumour model (“Virtual Tumour Clinical”) with Global Pharmaceutical Company, Merck (Merck Serono)
7 January 2015 36th EORTC-PAMM Winter Meeting
12 November 2014 Final Results for the year ended 30 June 2014
4 November 2014 Disclosure of Large Pharma partner Merck & Co.
EasyAP / Cardiac Toxicity Service
Physiomics has developed new services and technology for predicting cardiac toxicity that is 50% more accurate than the best current competitor.
- Cardiac toxicity is a leading cause of attrition in clinical studies and post-marketing withdrawal
- All candidate drugs must be screened for activity against the hERG potassium channel (FDA requirement)
- Optimal design of future studies
- Physiomics' EasyAP is a Web-based simulation and analysis tool for high-throughput ion-channel screening data. Please visit EasyAP website for more information.
- Physiomics' technology takes into account activity against hERG and two additional ion channels (hNav1.5 and hCav1.2) to deliver 50% greater predictivity than the best model currently available
We can offer Model Based Drug Development (MBDD) services which include:
- Population PKPD analysis of clinical data – select the right dose and regimen to maximise efficacy and minimise safety concerns
- Back-translational analysis – place emerging early clinical data within the context of the preclinical data package
- Optimal design of future studies – minimise no. of measurements to maximise information
- Preparation for due diligence – merge preclinical and clinical data to provide a holistic view of the compound
Physiomics' Virtual Tumour platform predicts optimal drug dosing, scheduling and combinations.
Physiomics helps pharmaceutical and biotechnology companies to determine optimal doses, schedules and combinations for their preclinical oncology candidates.
Virtual Tumour provides the following key benefits:
- Improve success rates for oncology candidates entering clinical studies, by increasing efficacy
- Reduce the time taken to do proof-of-principle
- Reduce the cost of xenograft study programmes
(fewer experiments needed)
- Provide regulatory agencies with a rationale for the design of a clinical study programme
Virtual Tumour Clinical
Physiomics' Virtual Tumour Clinical
Physiomics extends its Virtual Tumour platform to the clinic.
Virtual Tumour Clinical provides the following key benefits:
- Potential to improve response and survival rate in the clinic through enhanced drug potency
- Transform clinical decision making in terms of dose and schedule
- Model the dynamics of tumour size and circulating biomarkers available from individual patients
- Understand how changes in schedules and doses of drug combinations affect the dynamics of tumour burden